-synuclein, and that is a main component of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) anxiety, suggest that dysfunction in the intracellular proteinase programs, for example ubiquitin-proteasome system or lys

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